This webpage provides a detailed overview of the Whole-Brain Histogram Analysis (WBHA) method originally published in the Annals of Nuclear Medicine. Developed by Okuyama et al., WBHA represents a novel approach to brain PET image analysis. The methodology featured on this page introduces a newly advanced, MRI-based WBHA technique that builds directly upon the foundational work of Okuyama et al. Utilizing MRI allows for high-precision brain segmentation, which facilitates the calculation of standard quantitative measures of WBHA—specifically skewness and the mode-to-mean ratio (MMR)—alongside a novel quantitative metric: the Top 20% GW-ratio. When referencing this page for research presentations or academic papers, please cite both the original method by Okuyama et al. https://doi.org/10.1007/s12149-024-01956-y and our paper https://doi.org/10.1007/s12149-026-02218-9 .

Content

• What is WBHA ?

• Tutorial (How to Use) 

• Download & Link